If you have the money, then invest in BTC, Ether, and a decent amount of new altcoins that seem like they have a shot. Why not? Diversify and hope one or two are big winners.
It will be more profitable in long term to invest in Bitcoin only as bitcoin is the only cryptocurrency that is going to survive in the end as it has the largest support behind it as compared to other cryptocurrencies and have also shown enormous returns, so a wise man would put most of his eggs in a single basket that he is sure of is gonna win and not a few eggs in many baskets.