The best you can do it make it a "hard on memory usage" coin, like Monero, o
That is the closest to what I mean, but it still fails at the task, GPUS still have a huge advantage
Actually, on Monero the highest-hashrate stuff is still high-end CPUs like the AMD Epyc, Threadripper, and some of the top-end Intel many-core server CPUs.
The only GPU that can get into the 1000 hash/sec range is the Vega, per ONE report from ONE person - everything else that manages over 1000 hash/sec is a CPU - and the highest single-CPU report I've seen to date was an Epyc pulling over 3000 hash/sec vs the Vega at 1800.
The main issue is that nothing in cryptography that is in widespread usage uses anything but integer operations - which GPUs are perfectly capable of doing JUST as efficiently per clock cycle as any CPU can, but have a lot more "cores" to do the work with than any CPU does.
Even though GPUs clock a lot lower than CPUs (as a general rule on same-timeframe hardware), they have so many more "cores" that they can do a lot more work in total on anything that can be processed in a widely parallel way of work.
This also applies to ASIC hardware - the only reason you don't see a lot more algorithms with ASIC available is that most of the applicable coins would not generate enough income to make an ASIC unit able to pay off in a reasonable timeframe, coupled with the VERY HIGH COST to design, debug, and put an ASIC chip for mining into production that would be able to beat GPUs by a wide enough margin to matter.
This is the main reason there is no ASIC hardware for ETH mining - the uncertainty about "when is it going to go POS" has kept ASIC making companies uncertain that their miners would SELL - even though ETH would certainly make enough income to support ASIC if one COULD count on it being mineable for long enough.
The other reason is that ETH is hard on memory access - and ASIC *CAN'T* do much if any better on that than GPUs can do.
Wider RAM doesn't always help on that - otherwise the Fury and the Vega lines would be by far dominate ETH mining, instead of being high-end but NOT crazy-outstanding.