Worldcoin has a 15 second block target, so it gets a huge number of orphans and blockchain forks. I just wouldn't recommend mining any coin with less than a 60 second block target. But if the coin still makes profits even though you are getting a large number of orphans then why not.

And yes calculators will not factor in orphans. The calculators are designed for litecoin where orphans are extremely rare. Worldcoin by design (flaw) will have orphans like mad.

Also do note: you may not get any orphans showing up in your mining software, but the pool itself will be getting lots of orphans. So even if your software says the orphan rate is like 2%, the pool itself may be getting 15-20% orphans.