Sounds like the problem might not have been in the Trezor. First of all it is quite safe wallet and secondly not all your funds are gone, so there you go. I would look more into those addresses that got their coins stolen, I doubt some address was only partially emptied, I would assume that only some of your addresses were emptied and the ones that were are completely empty now. So I would trace my steps back about those addresses particularly, what is so special about them, what do they all have in common?

As for the altcoins, not only could be the same thing as I said above, but they also might have had trouble learning about how to use them and all, different wallets and making sure they can do in anonymously,...who knows...