I was considering allowing BitCoin payments on my site, where I sell my own software. I use VirtueMart and although there has been BitCoin payment integrated, it can't be used with other currencies so far. If it was able to do that, then it isn't really possible to peg a simple BitCoin price in the same way you can with other currencies because of the massive price fluctuations at the moment.
I therefore think an API to a BitCoin exchange for currency conversion, together with integration with open source e-commerce solutions would take a lot of the (projected) hassle factor out. I haven't looked into the bid/offer system in BitCoin but the pricing given to retailers through such a system would have to take into account potential market manipulation.
Ideally, as near instant as possible automated conversion to traditional currency would seal the deal. Then, for retailers, there wouldn't be any disadvantage.
Just throwing that out there, whilst simultaneously attempting to reach 50 posts without too much chaff.