I have 2 x GTX 980's, which is usually pretty close to the 1080ti. I use MultiPoolMiner, with this config https://github.com/aaronsace/MultiPoolMiner/blob/master/Start-MiningPoolHub.bat (and my own information of course). I've found that switching between Nicehash, Zpool, and MPH at the same time isn't worth my effort. Zpool takes too large of a fee for what I am able to output, and Nicehash is.. well Nicehash.

It'll benchmark all the available algo's and find which is most profitable for you and then do it's thing. On my setup it seems to be a mix between the Zcash, Zclassic, and Zcoin coins mostly.

I had to remove Tpruvot's CPU miners, but that's the only thing I really had to change.