A modification based off your suggestions. I will definitely consider a DOM or 2.5" SATA drive or BAMT via USB. The 3.5" is there for reference. I could have made it really boxy but I like the frame sticking out a bit. It gives it some flair.

http://i.imgur.com/j4BuBSHl.png

http://i.imgur.com/rrxGDLMl.png


And for vertical GPU placement, it can be positioned this way.

http://i.imgur.com/ls2AXtEl.png

http://i.imgur.com/z65b7IDl.png