Bug report:
On my Windows 7 machine, when Bitmessage is closed (through f.ex the tray icon), it will not re-open. Attempting to open it results in 2 Bitmessage.exe process instances, but no tray icon and no window.
Portable mode is on.
This is only sometimes reproducible. Deleting all .dat files resolves the problem, but wipes the "portable mode" setting.
If you go to Help > About, are you running v0.3.211 ? If not you might consider upgrading.