you can roll with atx's I use them on my lower power builds.
but once you get to a 1200 watt and up build the delta 2400 watt servers are better.
one thing I do find a breeze with server PSUs is indeed the connection management. you can go all 6pin risers (no Sata, no Molex), buy them in bulk and there is just less mind computions for managing PSU setups. with ATX you can always some connectors or pin cables depending on the brand & models you associate so there is more studying to undergo prior. some buy ATX based on power capacity alone then realize the units are not equipped properly for their rig need