This is my setup.

I run my monitor via the onboard Intergrated Graphics dvi port. I made the adjustments in the mobo BIOS to route everything to integrated - it showed up in two places. This way one of the vegas doesn't have to do dual duty.

Install windows. Disable all the "sleep and monitor dimming" settings.

Install AMD blockchain drivers. I installed the driver only. Unchecked everything else.

I did NOT flash my 56 to 64, still not sure if that is going to do much.

Did the reg-fix to all 4 cards.

Reboot.

On boot, disable all vegas. Then re-enable all vegas.

Run the script to apply the Overdrive settings. Fans kick in to 3000 rpms.

Run the miner (make sure you've updated the config for the miner so it can access dual mining on each vega). All four vegas running at 1950 h/s and about 150-170W. I haven't tried to adjust the mV to lower that draw.

I tried to install GPUz and HWinfo but I think that caused problems so uninstalled them. I do leave HWMonitor running on screen.

If I run into issues (like after I installed GPUz) I simply reinstall the AMD Blockchain drivers (drivers only again). Shut down. Power up and repeat the disable/enable -> overdrive script. I disable and re-enable the vegas on every boot up. I haven't had to reinstall windows yet - simply the AMD drivers. I think not having that crappy Wattman tool on the computer is half the battle.