Does this OS only work with these motherboards?
partially supported motherboard links:
ASUS B250 MINING EXPERT (13x gpu) Link
fully supported motherboard links:
ASRock H110 PRO BTC+ (13x gpu) Link
BIOSTAR TB250-BTC PRO (12x gpu) Link
ASRock H81 PRO BTC (6x gpu) Link
BIOSTAR TB85 (6x gpu) Link
MSI Z270-A PRO (6x gpu: 7x if you use 1x m2 adapter) Link
GIGABYTE GA-B250M-Gaming 3 (4x gpu) Link
BIOSTAR TB250-BTC (6x gpu) Link
ASUS Z270-F GAMING (7x gpu: 9x if you use 2x m2 adapters) Link
MSI Z170A GAMING M5 (7x gpu) Link
ASUS PRIME Z270-A (7x gpu: 9x if you use 2x m2 adapters) Link
GIGABYTE GA-Z270P-D3 (6x gpu) Link
ASUS PRIME H270-PLUS (6x gpu: 8x if you use 2x m2 adapters) Link
Or will it also work for my mainboard (Gigabyte h110-d3a) ??
I believe those are just ones that folks have confirmed that it works on. I am reasonably certain that nvOC will work as long as the underlying Ubuntu installation works on your hardware. For example, I have 2 rigs that run an X99 based board that is not even on that list at all. Give it a go and if you have issues, post them here and we will try to resolve them with you.