1. How many gpu per mb are you planning? EVGA's largest psu's will limit you... i would suggest server psu's if your serious. I run a single 2400w with 7 nvidia + 2 amd on win 10 without it breaking a sweat. No dual psu crap, but requires 240v power. If you are serious run your atx at 240v. Better efficiencies no matter the brand.
2. 570 & 580 in that order. Stupid deals lately...570 4gb for $199 usd after rebate. 4gb is a short sighted purchase but I don't usually mine eth. I just bought 4 more to max out my rig...check newegg.Com
3. #1 dictates your mb. I am on h110 pro btc+ and rock solid out of the box.
4. IMHO Vegas are power hungry but are getting better with recent mods...but $$$
My setup...
H110 pro btc+, I run 8gb memory, m.2 ssd and decent celeron cpu. I use a 250w pico psu and a 10 port Pwm fan controller. All cables are pcie 6 pin from server breakout to all devices, no molex or sata shit. Risers are v008s with 6 pin pcie power. 7 x 1070ftw, (4 x rx570 on the way), 1 x rx470, 1 x rx480. All on spotswood extruded aluminum frame. Total cost about $3800 by adding up in my head. Mostly used stuff from eBay and newegg fire sales.
My advice...
Get 8gb memory for mb... run a m.2 for faster virtual memory, i run a 30Gb swap file and the m.2 does help...get something better than G3950 cpu...buy new cards, used is more than new...buy good cards with no less than 2 yr warranty. Rx480 is great, rx580 is less efficient, rx570 offers good performance with less power and price. I will not buy a 580 and my 480 reference card lays down some good numbers but fools on ebay are paying $250+ for a 480 when you can buy a 570/580 for $200/220 new? Wtf?