From the terms of the investment, to the team backing the company. Read the whitepaper. On top of that, look at the fundamentals. Are you speculating on a pump and dump or can you actually see yourself using this product. It seems like everybody and their mother is issuing a cryptocurrency these days, find something good.
Avoid playing ICO roulette. Meaning, try not to throw money at every single coin or token that has an ICO. Historical data shows us this is generally less profitable than holding on to a select few strong coins.
Do not let yourself become emotionally attached to any coin you have, or any ICO you are thinking of getting into. I will not write about which recent ICOs I think were not worth it, since I'm sure we can guess as a collective group of smart readers. That being said, if a company adjusts the rules of the ICO abruptly and soon before the ICO, maybe it is a sign to take another look and decide if you still want to buy the coin.