The AMD blockchain drivers work with the Windows 10 v1709 Fall Creator's Update, but cause the UI to become unresponsive. I switched back to using the blockchain drivers with Windows 10 v1703 and they work fine. You can also try the latest Crimson Relive v17.1x.x drivers that are compatible with the Windows 10 FCU and toggle each GPU to 'compute' mode from 'gaming' in AMD settings. The latest drivers apply the blockchain driver Dag fix when in compute mode, but I switched back to using the blockchain driver with v1703 because Afterburner won't work with the latest Crimson Relive drivers .