Hi,
I re-installed Ledger Nano S(te new one) i took al the wallet apps of, disabled Adblock and on the ledger nano s i turned browser support off.
I think that,s all i cault find on forums and other troubleshoot page,s.
I faced the same problem this afternoon, I set up the wallet correctly and installed the Chrome extension turned off browser in settings etc. Still I wasn't able to open the wallet, nothing happened.
You need to install the Chrome extension. I have lost 1 hour today to figure that I don't need the manager wallet app Chrome extension but the "Bitcoin wallet" extension.
https://chrome.google.com/webstore/detail/ledger-wallet-bitcoin/kkdpmhnladdopljabkgpacgpliggeeaf?utm_source=chrome-app-launcher-info-dialog