I had the same problem with the start button and programs requiring right clicking to start and overall sluggishness on my 6 vega rig with asrock mobo. Wiped out windows 10 (1709) fall creator's update and installed win10 1607 with blockhchain drivers and everything has been working great. Uptime has been about 2 weeks+ mining 24/7 at 1970 hs per card.