Mine when difficulty is low even if it's not the #1 most profitable right now then hold and wait for 2-100x price increase.
2 - 100X ??!!?? Have you ever experienced x100

? I guess some "shitcoin" with pump and dump, right?
Ethereum was worth just 8 dollars a year ago, 800 now.
As for the initial question, yes, monero is profitable. Even old hardware can mine it just fine and power consumption is lower compared to mining other coins.