Starting with the teams playing home like Tottenham, Chelsea, Manchester United, Liverpool.
I expect a win for these 4 teams against Southampton, Brighton, Burnley, Swansea. The lasts' performance this season is not very well.
So my bet here will be :
Tottenham VS Southampton : 1&2+
Chelsea VS Brighton : 1&NG&2+
Manchester United VS Burnley : 1&NG
Liverpool VS Swansea : 1