Bet at a Bitcoin only sportsbook. LOL! You lose, but BTC moons...
There is no sense, when you lose you won't benefit on the price increase of bitcoin and that is not smart.
Being smart is to know your limit in gambling because that would help you achieve the entertainment you are looking, even if you lose you can still have fun and you can continue to gamble unlike other people who end their journey in gambling very early because of lack of discipline.
Indeed , when you lose that means you lose bitcoin as well. Even if bitcoin price keep getting higher, you are not getting anything because you lose your coin. Why do you want to lose your coin if you can hold your coin. If you just hold your or even lose small amount then that would be much better than losing alot when you gamble