Never got into the whole HW wallet thing. Are they worth it?
Is there any one big significant drawback?
Someone said one brand of hardware wallet only had enough memory to let you store a few altcoins on it in addition to your bitcoins. I can't remember what brand it was and have never tried them myself.
The ledger nano s only lets you keep three or so wallet 'apps' at a time. But deleting a wallet app does not 'remove' the associated coins: as soon as you load the wallet app again with your pin, you can access your 'stored' coins again. It's apparently a security measure to minimize the amount of hackable storage. The ledger blue has more storage.
I also like the fact that hardware wallets are compatible with Electrum and maybe other wallet apps or browser apps, too. So you don't have you use the packaged wallets if you don't want to.