I responded in the wrong thread!

How come you have never mined any neosh*tcoin ? Some of them do shoot up to incredible heights after initially being cheap and low difficulty. I dedicated one rig to these coins and a 2 out of 3 coins do make it big. I think neo is memory heavy, I do have like +400 on my 1070s.
I'm pretty new at this, but I found that the same OC settings for Equihash work well for Neoscrypt, too.