Oh right, my rig is gonna be 8 AMD cards, and 4 NVIDIA cards!

Will that be a massive problem?
How do I manage my devices? Can't I do it all on one monitor and use dummy plugs whilst managing the overclocking?
which is why 12 card rigs can be stupid
there are a few ways to do it
if you want to mine on nicehash
you can run multiple instances and setup the nvidia to one coin and the amd to another coin
but in the end both coins will be auto converted to btc.
I run a cpu and an amd on nicehash doing cryptonight
I then run a second instance for the 2 nvidia cards for zec
on one I check the cpu and the amd
on the other check the nvidia but in the end they all become btc