Of course, yes! It wouldnt hurt that much if some of your hard earned Bitcoins would be given for donations. You are not giving everything anyway. Not every people will experience the same opportunity that has knocked on your doors. Some are lucky enough to live a comfortable life while some has already lost the war of poverty even before they could say their first words. Sometimes we cannot always associate poverty with laziness. Many are already doing their very best but still they couldnt barely put food on the table.
Well, if Im going to give to the poor and needy I will not going to give my bitcoin rather I give them cash or groceries because some of the poor and needy don't spend time to internet and don't know about bitcoin or crypto currencies so better give them cash.