Something special would be to bet on the next LOL or DOTA 2 championship. A lot of crypto enthusiasts are gamers. The pricepool for the 2017 DOTA2 tournament "The international" was stunning 25 Million USD (source https://www.esportsearnings.com/comparisons/zcdd-dota-2-vs-lol).

sportbetting
e-sportbetting

I'm not sure if there is any possibility to bet on esport yet.