The Trading Fees
Bittrex are not notorious for super high fees, but still: 0.25% are 0.25% per transaction – and this can become significant over time.

Binance takes 0.1% which is a fivefold less than on Bittrex. It gets even better if you hold the BNB tokens in your account, as if you pay the fees with BNB instead of BTC you get a whopping 50% discount, making it 0.05% fees per transaction.

BITTREX: 0 | BINANCE: 1