Mostly no.
The Diff you mine at is not expected to affect your rewards unless you set it WAY too high.

If you do set it WAY too high, then you are still expected to get the same reward but with higher variance.

The logic of how Diff works is like this:
Say I am mining at Diff 1,000 and I find 200 shares >= 1,000 thus reward is based on 200,000 Diff
If instead I was mining at Diff 10,000 you would expect there to be 20 shares (on average) in that 200 shares, that are >= 10,000 thus you'd expect your reward to be based on, again, 200,000 Diff

It's all 'expected' statistics and you absolutely cannot game it

So there's usually no point changing it unless you have an old miner that wont display diff properly - but even in that case it doesn't affect your expected reward - just the display on some of the old bitmain miners wasn't correct if you had an exact power of 2 for the mining diff - in that case you could set it in the Management Page to be a little higher.