Anyone run with tb250-btc pro with 12 amd cards. Or can i run same 12 x rx 580 cards with simplemining os? I'cant find any info about this.
Yes you can. SMOS supports 12 cards so if you change your bios settings and update the latest bios for mobo you can smoothly run 12 rx580 cards on biostar tb250 btc pro.
There is nothing smooth about those Biostar TB250 boards. They are more difficult than they need to be. Their previous TB85 boards were much easier to get up and running. Be careful about updating to the latest BIOS version. I had difficulties with the TB250-BTC and BTC+ boards until I rolled back the bios to a much earlier 330 version.