I don't get what you mean by profitable, I currently mine YenTen, I have a Xeon with 4 cores running all the time at about 90H/s per core, and i7 that runs all night and most of the day on 8 cores at about 70H/s per core, an i5 running continually with 4 cores at about 40H/s and another I& that runs for a few hours at night at about 90H/s

Profit... about 4-6 coins a day, doesn't matter what pool I use, yentencoin, bunnymining, antminerpool all very low payouts in my opinion.