Wow you have a lot of bitcoins all i can say is that it really depends on you in your current situation.You can invest in some altcoins or invest it outside crypto.If you doesnt really need to sell for now maybe you should try to hold it.Every bitcoin or money is a hard earned one but if you have a good heart for the poor or some legitimate charities i just thought if you could share some of it.
In some ways 420 bitcoins are a lot of money if its converted to fiat.Im not saying that you really have to do it because it just really depends on you if you are convenient enough of helping other people as well because in todays times rare are those people who would share those blessing that they owned.