1. Outside of Windows Defender, should I be running an anti virus software?
No, just make sure the firewall is on and dont surf any dodgy sites / download anything dodgy
2. Are there any Bios Updates or tweaks for the MOBO?
is the the pro or pro plus (+) ?
3. WHat kind of tweaks can I use for the cards?
stick to overclocking with afterburner, your done .