It's a no-brainer. Even the most miserly understand that it benefit their own society. The question is which charity you should donate to. Sure there are trusted long-lived charities out there but just go for one that gives the most bang out of your bucks.
Ideally it would be somewhere closer to home so you can see the effects of your donation. Maybe if you also have the time to spare, you can set-up one of your own and have it funded via cryptos for the widest reach.
Is this the group where that female professional poker belong to? Forgot her name but seen her a lot on Big Think and other channels.
EDIT: Forgot to post the link.
https://www.youtube.com/watch?v=4-ZGb2IJhfk