With a modded Bios on RX 470/480 and 570 cards you need to use the AMD pixel patcher to bypass the signature check or you will have a code 43 error in the Windows Device Manager and they won't work. Most RX 580's don't need the patcher. Apply the patcher after installing or updating the AMD driver and reboot. If you are still having trouble, try removing the drivers in safe mode using DDU, install the latest AMD driver, apply the pixel patcher and toggle compute mode on in AMD settings for all the cards.

https://www.monitortests.com/forum/Thread-AMD-ATI-Pixel-Clock-Patcher