This sounds like an awesome idea, but I'm confushed as to where you have the profile disable the GPUs? i looked at adding a profit profile and nowhere does it let you specify the gpu to use.
not through the GUI you cannot, you have to parse that through the command line parameter and probably best to do that with each software unless you are only using 1 software exclusively or all software you use share same --device flag through the command line. (In which case you can just parse that through the managed miner itself, right click miner -> Properties, Command Line and enter the appropriate parameter through the text field)

So once you have a miner assigned to a profile, right click on miner and select "Edit Profit Profile".
Go to each enabled software and click the Configure button, make sure you read each software's usage, they may be using different flags and arguments for the settings
th Command line parameters to mining software txt box is where you parse custom commands, for example in the picture, I set a different Intensity through the -I flag for lower end hardware.

The command line references for the common software you'd likely be using can be found in case you are not familiar at using windows CMD to trigger the help screen:
https://github.com/tpruvot/ccminer/blob/windows/README.txt - ccMiner
https://bitcointalk.org/index.php?topic=1433925.0 - Claymore Dual Eth
https://bitcointalk.org/index.php?topic=1670733.0 - Claymore ZCash
https://bitcointalk.org/index.php?topic=2021765.0 - dstm ZCash