What would be the best setup to get started?
Depending on what kind of crypto currency are you going to mine. If you want to mine bitcoin then you will need to have a huge amount of capital for the ASIC equipment and also for the monthly electric bill which cost a lot.
If you were to mine altcoin then i would suggest to you that you mine monero, ethereum and most coins who in the top 10 of coinmarketcap. They are much more easy to mine compared to bitcoin and the cost for mining rig will also be lesser.
Profit varies on what coin you choose to mine and the amount of money you will release as a capital.