Personally I have only GDAX set up to buy LTC/ETH/BTC and move some to Binance for ALT trades.
Extremely happy with Binance, looking for another ALT site to store liquid trading pairs.

I can't get on Bittrex and that's looking to be a good thing. Not sure they are in for long haul.
And I checked an Exchange review site but sadly not one Exchange earned 4-stars.
All were rated 3-stars and below.

Also, I see BitFlyer, Japan's largest exchange, has landed in USA but not in my state yet.

Which ones are you happy with and what do you use them for?