As many here have already mentioned, once the keys to are wallet are gone the coins inside are stuck for ever.
I think that with time, that is going to happen many times.
And that means as well that the number of circulating bitcoins is being reduced. That will contribute to an increase in price.
Maybe one day a bitcoin will be a very rare good and accordingly expensive.
That's why we should prepare a legacy plan to indicate whom will access our wallets, private keys in case we die. Usually we used to write our physical belongings like house, field, car etc and now we need to put our private key and all the necessary information into our legacy.