Big blockchains like BTC,ETH,NEO,ETC will still be available even in 2022. I hope, In 2019 we can see the full releases of EOS and especially TEZOS, which are "Ethereum killer".
I was going to write my coins but you already have. I would just recommend those ones. Big comunities, important developments coming and they've proved to be reliable. The same opinion with EOS and Tezos (I hope the solved this freaking situation they have).
And I'd like to recommend to invest also in other "classical" reliable coins like Litecoin and others focused on privacy like Monero and/or Zcash.