1) Nano ledger only supports up to 5 applications/ coins i believe? -- https://www.reddit.com/r/Bitcoin/comments/6suu4c/how_many_apps_can_you_install_on_a_ledger_nano_s/

2) Trezor only supports 10 coins i think - https://coinsutra.com/trezor-supported-coins/

3) That's going to be an extreme hassle but if you're going to hodl this could be possible.

4) If you're only planning on buying ERC20 tokens.

5) Exodus, https://www.exodus.io/ Jaxx, https://jaxx.io/ ( I believe they had security issues in the past so use with care. Coinomi -https://coinomi.com/ ( Android/IOS) over 270 coins.