Lux and Bitcore seem to be the new goto for better then average, but not always profit. There really aren't any major niches anymore. New miners obliterated those. If you're lucky you'll find a coin that will give you +10-20% for about a day~ before it's on par or worse then something you can find on whattomine. Profits actually aren't THAT bad even though they're declining significantly, we're still well ahead of where we were in parts last year.

You can always gamble with unlisted coins.