One of my z220 sff came a very good Xeon CPU but 3 slots as you said.
It is really good for running moonlander usb sticks or sidehack 2 pac
Yeah once I installed the HP Z210, it's been rock stable. I expected problems due to their proprietary nature, but had to see if it would work for my purpose. I would say the only issues I had are the ones I've caused

Those newer HP Z220 are quickly flooding into the used PC market, so I'm sure they'll be very cheap whenever these become old and unusable.
Otherwise uptime has been very good for Windows. Very low maintenance, ever since I added automatic restart scripts on a 24 hour interval and watchdog scripts to restart and log automatically whenever it notices 0% GPU use or network disconnection. I take a little hit while it restarts though.