only been here with one rig for a day but this technique is working very well so far. set the autopayouts to cryptsy addresses and set cryptsy to autosell desposits. makes this pool quite good.
On illiquid coins where there is a big spread between bit and ask prices, you are losing some profitability by always selling at the lowest price.
On the other hand, it is all automated, so saves you time.
As an example, in the SREC/BTC market:
2013-09-02 14:18:06 Sell 0.00087000 5.47583000 0.00476397
2013-09-02 14:11:30 Sell 0.00087000 10.00000000 0.00870000
2013-09-02 14:08:17 Buy 0.00099598 15.88449000 0.01582063
2013-09-02 14:08:15 Buy 0.00099421 1.13551000 0.00112894
2013-09-02 14:08:14 Buy 0.00099421 20.00000000 0.01988420
2013-09-02 14:01:40 Sell 0.00087000 3.35533000 0.00291914
2013-09-02 13:51:08 Sell 0.00087000 1.00352000 0.00087306
People were prepared to pay almost 1mbtc, but the automated sales were getting only 0.87mbtc.