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The ledger may incur a second twist, and that is they will most likely be changing the seed word format from 25 to 24 words to match the rest of the wallets they support. The only concern here is there is a reliable way to either convert these wallets to the 25 word form or somehow else see their seed word format supported by other software (inc. the standard cli and GUI).
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The 25th word is just a checksum and not actually a part of the seed itself - it's always one of the seed words and is calculated from the seed itself, so I don't think this is an issue at all.