Thanks for starting this thread. Guillermo del Toro is a lock for Best Director, IMHO. Put some $ down on him before the British Academy of Film and Television Arts (BAFTAs), but he strengthened his case as the runaway favorite when he took the award over Nolan (who is a British director).
Odds have definitely reflected that from the -200ish -> -1000+ drop since then, but I still think there is value there if you can find it at -1000 or less (Bovada, BetOnline) for a 10%+ ROI.
Coco is another lock, but the odds are ridiculous on that one now (like -4000, -5000 range).
BOL
Can't believe The Shape of Water is favourite in Best picture. Quite boring and too much extended. I don't think that my personal favourite Dunkirk shipped it. But I'll keep my fingers crossed for Three Billboards Outside Ebbing.