If AMD only setup, then ethos else simplemining. Do you have time and patience? then install centos7/ubuntu and compile the miners yourself (thats what i do).
I stay away from windows mostly because i am comfortable with linux. Note, you will see a drop of about .5mhz - 1mhz in linux (claymore). But i think you can ignore that.
Have you been able to get centos7/ubuntu to work with a mix of Nvidia and AMD cards with the B250?