Are we still talking about the Eyeboot USB hub, the one which comes bundled with a 5V power supply? Or the Eyeboot USB hub, the one that comes with a built-in 5V power supply?
No, it doesn't use 12V. No reason it would, since USB doesn't use 12V and why build a 12V to 5V down-converter good for 60A into a thing when you can get a 5V supply directly?
The 24-pin plug from the PSU also carries 5V, 3.3V, -12V, -5V, 5V standby and some signal lines. Don't forget that.
So no, a power supply with a 22A 5V rail secondary to its main 12V output is in no way better than a 60A 5V dedicated supply.
With these hubs, use the Logisys 550 watt PSU. They are on Newegg for under $40. They have 5V @38-40A. Dont use anything bigger (575W or 650W) because they upped the 12V and not the 5V