I'm running Windows 10 with 5x AMD 570 1x1070 and 1X 1080

All run ok but as others said the OC tools seem hit or miss.

Afterburner will not detect any AMD cards so i use OverdrivenTool for AMD and EVGA tool for the Nvidia.

1 annoyance i have is if there is a driver issue and you run DDU then you need to reinstall 2 sets..Nothing major though.