Yeah it is possible. I remember the back that I've been read last week about the history of medicine on how it was discovered by every passionate person. Some of them experienced discouragement but they keep on going to continue the thing which they discovered in order to develop the it to become more helpful and yes they made it. It is under by self study by observing things and by that we are now enjoying their works. There maybe negative effects for not having a formal study but as long as your learning will contribute that will be a great success not just for self but also for others.