The edge should under no circumstances be changed. The 1% edge is why just-dice has a market advantage and 2 million BTC wagered.
If he raises it, gamblers will instantly go play at a competitor with 1%. Adjust the max bet if you'd like, but changing the edge would be a terrible business decision.
Also what I think. A house edge at 1% is simple and as doog says no need add small print like "except if you are betting more than 50 btc...". Then what do you do if there is a huge swing in the value of btc? You have to start taking this into account too... maybe in two years betting 10 btc is like betting 50 now? I foresee endless discussion about the level at which the house edge should start going up. Spare us the aggravation and just leave it at 1% for all bets.
Someone suggested an investment cap, I can't agree with that either. Fixing a maximum when the price of bitcoin can be volatile fails anyway as an attempt to fix the max bet in the longer term. Besides I much prefer to let investors set the maximum bet it in accordance to the risk they want to take.