Definitely base your investment choices on fundamentals!
You don't want to hold a shitcoin through a whole bearmarket, just because you expected a random pump without any fundamental news.

Also always do your due diligence. Don't blindly trust so-called veterans like John McAfee, who recently shilled coins that stopped being developed years ago (f.e. see ReddCoin: https://github.com/reddcoin-project)

Check the team members' biographies, Github activity, partnerships, etc. to make sure your investment has a longterm perspective.

Imho lots of good calls already in this thread.

My personal favourites are (in no particular order):

- Stratis
- IOTA
- Zilliqa

Also make sure to check out Dfinity, Cosmos and the DAGLabs coin, though they haven't entered the market, yet.