The first 10 coins on the coinmarketcap are the best coins that you can invest and make really good money in years come. Bitcoin, ethereum, ripple, zcash, dash, litecoin and some many other that has good capitalization are some of the coins you can actually invest and make good money.
It really depends on what you're looking for, if what you want are long term profits then investing in the first 10 coins in the market cap be a really good choice since its very unlikely those coins are going to disappear, however if what you want is to make your investment grow many times over in the short term you have no option but to invest in altcoins with very low market caps.